个人简介

周立兵，比利时鲁汶大学神经生物学博士，暨南大学粤港澳中枢神经再生研究院教授、博士生导师。从事神经生长发育、脑脊髓损伤再生修复研究；在Science、Brain、JEM、PNAS、Nat Comm等国际刊物发表SCI论文60余篇；主持承担973课题、国家自然科学基金、广东省和广州市等重大科技专项20余项；申请相关专利8项、授权4项；获教育部“新世纪优秀人才支持计划”、广东省特支计划“百千万工程”领军人才等称号。

主要研究方向

（1）Celsr基因家族在调控神经发育和促进神经再生修复的机理机制；

（2）干细胞及其衍生物、基因干预和小分子药物治疗脑脊髓损伤和退行性疾病。

论文列表

1.   Chen B., Li F., Jia B., So K.F., Wei J.A., Liu Y., Qu Y., Zhou L*.（2022）, Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response, Mol Neurobiol. 59:5179–5192.

2.    Wen Q^#, Weng H^#, Liu T, Yu L, Zhao T, Qin J, Li S, Wu F, Tissir F, Qu Y^*, Zhou L^* (2021). Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain, 145 (2): 670-683.

3.    Zhou, Q., Qin, J., Liang, Y., Zhang, W., He, S., Tissir, F., Qu, Y., Zhou, L* (2021). Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity. iScience. 24 (102812)：1-17

4.   Qin J^#, Wang M^#, Zhao T^#, Xiao X, Li X, Yang J, Yi L, Goffinet AM, Qu Y^*, Zhou L^*（2020）. Early Forebrain Neurons and Scaffold Fibers in Human Embryos.Cerebral Cortex.30 (3):913-928

5.   Sun G, Yang S, Cao G, Wang Q, Hao J, Wen Q, Li Z, So KF, Liu Z, Zhou S, Zhao Y, Yang H, Zhou L*, Yin Z* (2018) γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury. Journal of Experimental Medicine. 215 (2): 521-535

6.    Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y^* and Zhou L^*(2016). Celsr3 and Fzd3 organize a pioneer neuron scaffold to steer growing thalamocortical axons. Cerebral Cortex. 26 (7): 3323-34.

7.    Qu Y, Huang Y, JFeng J, Alvarez-Bolado G, Grove E, Yang Y, Tissir F, Zhou L* and Goffinet A*. (2014) Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 111(29):E2996-3004.

8.    Feng J, Xu Y, Wang M, Ruan Y, So KF, Tissir F, Goffinet A, Zhou L* (2012) A role for atypical cadherin celsr3 in hippocampal maturation and connectivity. J Neurosci 32:13729-13743.

9.   Zhou L, Gall D, Qu Y, Prigogine C, Cheron G, Tissir F, Schiffmann S, Goffinet AM. Maturation of “cortex isolé” in vivo (2010). J Neurosci 30(23): 7928-39.

10.     Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F (2008) Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science320:946-949.

联系方式

地址：广州市黄埔大道西601号暨南大学粤港澳中枢神经再生研究院506室，邮编：510632

电话：020-85228362，传真：020-85223563

电邮：tlibingzh@jnu.edu.cn