个人简介

曲宜波，暨南大学粤港澳中枢神经再生研究院研究员，博士生导师，主要研究神经发育与再生的分子调控机制。解析了神经细胞极性异常相关疾病的发生发展机制，并对发育关键基因在成体神经再生中的功能展开研究，探索可促进神经损伤后再生修复的调控分子靶点。2006年毕业于清华大学生物科学与技术系，获得理学学士学位；2011年毕业于比利时法语鲁汶大学，获得生物医学与药学博士学位。研究成果在Molecular Psychiatry、Brain、PNAS等期刊发表。获国家自然科学基金优青、广东省卓越青年团队、广东省杰青等项目资助。

研究方向

1、  神经发育相关疾病的机制研究。

2、  神经损伤后再生修复的调控机制研究。

代表论文

1)    Chen B, Wang L, Li X, Shi Z, Duan J, Wei J, Li C, Pang C, Wang D, Zhang K, Chen H, Na W, Zhang L, So KF, Zhou L, Jiang B*, Yuan T*, Qu Yibo*. Celsr2 regulates NMDA receptors and dendritic homeostasis in dorsal CA1 to enable social memory. Molecular Psychiatry，2022 Jul 4. doi: 10.1038/s41380-022-01664-x.

2)    Li C, Wei J, Wang D, Luo Z, Pang C, Chen K, Duan J, Chen B, Zhou L, Tissir F, Shi L, So KF, Zhang L*,Qu Yibo*. Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses. Progress in Neurobiology, 2022 Sep 8;219:102352.

3)    Liu A, Yu L, Li X, Zhang K, Zhang W, So KF, Tissir F, Qu Yibo*, Zhou L*. Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair. Glia, 2023 Apr 26; DOI: 10.1002/glia.24378.

4)    Wen Q, Weng H, Liu T, Yu L, Zhao T, Qin J, Li S, Wu Q, Tissir F,Qu Yibo*, Zhou L*. Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain, 2022 Apr 18;145(2):670-683.

5)    Qin J, Wang M, Zhao T, Xiao X, Li X, Yang J, Yi L, Goffinet AM, Qu Yibo*, Zhou L*. Early Forebrain Neurons and Scaffold Fibers in Human Embryos. Cerebral Cortex,2020 Mar 14;30(3):913-928.

6)    Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Yibo*, Zhou L*. Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons. Cerebral Cortex， 2016 Jul;26(7):3323-34.

7)    Qu Yibo, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A (PNAS), 2014 Jul 22;111(29): E2996-3004.

8)    Tissir F#, Qu Yibo #, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nature Neuroscience,2010 Jun;13(6):700-7.

9)    Qu Yibo#, Glasco DM#, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. Journal of Neuroscience, 2010 Jul 14;30(28):9392-401.