个人简介

       殷鹏，博士生导师，2019年至今粤港澳中枢神经再生研究院研究员，2015-2019年美国埃默里大学博士后，2012-2015年中科院遗传发育所助理研究员，2012年毕业于复旦大学上海医学院获博士学位。十多年来一直从事神经退行疾病研究，包括建立和利用猴、猪、鼠等动物模型，对衰老相关肌萎缩侧索硬化症、亨廷顿舞蹈症、阿兹海默症的病理机制和治疗靶点进行分析。在Acta Neuropathol, Alzheimers Dement, Autophagy, Cell Rep, Protein Cell等刊物发表论文。主持或结题国家自然科学基金面上项目、青年项目、重大子项目、广东省面上项目、中央高校交叉项目等。

近五年代表性论文

1.     Ou K, Jia Q, Li D, Li S, Li XJ, Yin P. Application of antisense oligonucleotide drugs in Amyotrophic Lateral Sclerosis and Huntington's disease. Transl Neurodegener (2024, IF=10.8)

2.     Zhang C, Jia Q, Zhu L, Hou J, Wang X, Li D, Zhang J, Zhang Y, Yang S, Tu Z, Yan X, Yang W, Li S, Li XJ, Yin P. Suppressing UBE2N ameliorates Alzheimer’s disease pathology through the clearance of amyloid-β. Alzheimers Dement (2024, IF=14.0).

3.     Bai D, Deng F, Jia Q, Ou K, Wang X, Hou J, Zhu L, Guo M, Yang S, Jiang G, Li S, Li XJ, Yin P. Pathogenic TDP-43 accelerates the generation of toxic exon1 HTT in Huntington’s disease knock-in mice. Aging Cell (2024, IF=8.0).

4.     Zhu L, Deng F, Bai D, Hou J, Jia Q, Zhang C, Ou K, Li S, Li XJ, Yin P. Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain. Cell Mol Life Sci (2023, IF=8.0).

5.     Jia Q, Bai D, Zheng X, Zhu L, Ou K, Wang X, Tong H, Zhang Y, Wang J, Zeng J, Yan S, Li S, Li XJ, Yin P. Comparing HD knock-in pigs and mice reveals the pathological role of IL-17. Cell Rep (2023, IF=8.8).

6.     Zhu L, Li S, Li XJ, Yin P. Pathological insights of Amyotrophic Lateral Sclerosis animal models: comparisons, limitations and challenges. Transl Neurodegener(2023, IF=12.6)

7.     Bai D, Zhu L, Jia Q, Duan X, Chen L, Wang X, Hou J, Jiang G, Yang S, Li S, Li XJ, Yin P. Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington’s disease knock-in mice. Prog Neurobiol (2022, IF=10.9)

8.     Jia Q, Li S, Li XJ, Yin P. Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics. Front Immunol(2022, IF=8.8)

9.     Yin P,Li S, Li XJ, Yang W. New pathogenic insights from large animal models of neurodegenerative diseases. Protein Cell (2022, IF=21.1)

10.Yin P, Bai D, Deng F, Zhang C, Jia Q, Zhu L, Chen L, Li B, Guo X, Ye J, Tan Z, Wang L, Li S, Li XJ. SQSTM1 mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy (2021, IF=16.0)

11.Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. EMBO Rep (2020, IF=9.1)

12.Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol (2019, IF=18.2)