个人简介

      殷鹏，博士，2019年7月至今任粤港澳中枢神经再生研究院，研究员。2012年于复旦大学获博士学位。2012-2015年于中科院遗传发育所任助理研究员。2015-2019年于美国Emory大学进行博士后研究。多年来一直从事衰老相关的脑遗传性神经变性疾病研究，尤其在建立非人灵长类神经退行疾病模型上积累了丰富经验。主要研究方向为：利用猴、猪和小鼠等多种动物模型，对肌萎缩侧索硬化症、亨廷顿舞蹈症的病理机制和治疗靶点进行分析。在Acta Neuropathol，Autophagy，Cell Rep，EMBO Rep，Prog Neurobiol，Protein Cell等刊物发表论文，曾主持或结题国家自然科学基金面上项目、青年项目，广东省自然科学基金面上项目、中央高校基本科研业务交叉专项、广州市科技计划项目等。

代表性论文

1.  Zhu L, Deng F, Bai D, Hou J, Jia Q, Zhang C, Ou K, Li S, Li XJ*, Yin P*. Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain. Cell Mol Life Sci (2024) (*Co-Corresponding, IF= 8.0)

2.  Jia Q#, Bai D#, Zheng X#, Zhu L, Ou K, Wang X, Tong H, Zhang Y, Wang J, Zeng J, Yan S*, Li S*, Li XJ*, Yin P*. Comparing HD knock-in pigs and mice reveals the pathological role of IL-17. Cell Rep (2023). (*Co-Corresponding, IF=8.8).

3.  Zhu L, Li S, Li XJ*, Yin P*. Pathological insights of Amyotrophic Lateral Sclerosis animal models: comparisons, limitations and challenges. Transl Neurodegener(2023). (*Co-Corresponding,IF=12.6)

4.   Bai D#, Zhu L#, Jia Q, Duan X, Chen L, Wang X, Hou J, Jiang G, Yang S, Li S, Li XJ*, Yin P*. Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington’s disease knock-in mice. Prog Neurobiol (2023). (*Co-Corresponding,IF=10.885)

5.  Jia Q, Li S, Li XJ*, Yin P*. Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics. Front Immunol(2022).  (*Co-Corresponding,IF=8.786)

6.  Yin P, Li SH, Li X-J, Yang W*. New pathogenic insights from large animal models of neurodegenerative diseases. Protein Cell (2022).  (IF=15.328)

7.  Yin P*, Bai D, Deng F, Zhang C, Jia Q, Zhu L, Chen L, Li B, Guo X, Ye J, Tan Z, Wang L, Li S*., Li XJ*. SQSTM1 mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy (2022).  (*Co-Corresponding, IF=16.016)

8.  Bai D#, Yin P#*, Zhang Y, Sun F, Chen L, Lin L, Yan S, Sen Yan, Li S, Li XJ*. Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Hum Mol Genet (2021).  (#Co-first, *Co-Corresponding, IF=6.150)

9.   Yin P*, Bai D, Zhu L, Deng F, Guo X, Li B, Chen L, Li S*, Li XJ*. Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system. Exp Neurol (2021).  (*Co-Corresponding, IF=5.620)

10.  Yin P*, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S*. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. EMBO Rep (2020). (*Co-Corresponding, IF=9.071)

11.  Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y*, Li S*, Li XJ*. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol (2019). (IF=18.174)