个人简介

         殷鹏，博士生导师，2012年毕业于复旦大学上海医学院获理学博士，2012-2015年中科院遗传发育所助理研究员，2015-2019年美国埃默里大学博士后，2019年至今粤港澳中枢神经再生研究院研究员，博士生导师。从事神经退行疾病研究已十多年期间，通过建立非人灵长类猴、人源化鼠等实验动物模型，对衰老相关肌萎缩侧索硬化症（渐冻症）、亨廷顿舞蹈症、阿兹海默症的病理机制和治疗靶点进行分析。以最后通讯或第一作者在Nature Communications (2026), Autophagy (2025, 2021), Alzheimers & Dementia (2024), Cell Reports (2023), Acta Neuropathologica (2019) 等刊物发表论文。主持国自然面上项目、重大子项目、青年项目、国家实验室项目、广东省面上项目等。  

近五年代表性论文  

1.    Jia Q, Zhu L, Li D, Nan Z, Hou J, Zhao Y, Zhu G, Ou K, Guo M, Dui H, Liu X, Yan X, Yang S, Huang L, Fan D, Li S, Li XJ, Yin P(最后通讯). Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology. Nature Communications (2026, IF=18.1).

2.    Ou K, Wang X, Guo M, Li D, Zhang C, Chen L, Hou J, Jia Q, Zhu L, Yang S, Li S, Li XJ, Yin P(最后通讯) Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice. Autophagy (2025, IF=14.3).

3.    Ou K, Jia Q, Li D, Li S, Li XJ, Yin P(最后通讯). Application of antisense oligonucleotide drugs in Amyotrophic Lateral Sclerosis and Huntington's disease. Translational Neurodegeneration (2025, IF=15.2)

4.    Zhang C, Jia Q, Zhu L, Hou J, Wang X, Li D, Zhang J, Zhang Y, Yang S, Tu Z, Yan X, Yang W, Li S, Li XJ, Yin P(最后通讯). Suppressing UBE2N ameliorates Alzheimer’s disease pathology through the clearance of amyloid-β. Alzheimers & Dementia (2024, IF=13.1).

5.    Bai D, Deng F, Jia Q, Ou K, Wang X, Hou J, Zhu L, Guo M, Yang S, Jiang G, Li S, Li XJ, Yin P(最后通讯). Pathogenic TDP-43 accelerates the generation of toxic exon1 HTT in Huntington’s disease knock-in mice. Aging Cell (2024, IF=8.0).

6.    Jia Q, Bai D, Zheng X, Zhu L, Ou K, Wang X, Tong H, Zhang Y, Wang J, Zeng J, Yan S, Li S, Li XJ, Yin P(最后通讯). Comparing HD knock-in pigs and mice reveals the pathological role of IL-17. Cell Reports (2023, IF=8.8).

7.    Zhu L, Li S, Li XJ, Yin P(最后通讯). Pathological insights of Amyotrophic Lateral Sclerosis animal models: comparisons, limitations and challenges. Translational Neurodegeneration (2023, IF=12.6)

8.    Zhu L, Deng F, Bai D, Hou J, Jia Q, Zhang C, Ou K, Li S, Li XJ, Yin P(最后通讯). Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain. Cellular and Molecular Life Sciences (2023, IF=8.0).

9.    Bai D, Zhu L, Jia Q, Duan X, Chen L, Wang X, Hou J, Jiang G, Yang S, Li S, Li XJ, Yin P(最后通讯). Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington’s disease knock-in mice. Progress in Neurobiology (2022, IF=10.885)

10.   Yin P(第一作者),Li S, Li XJ, Yang W. New pathogenic insights from large animal models of neurodegenerative diseases. Protein & Cell (2022, IF=15.328)

11.   Yin P(第一作者), Bai D, Deng F, Zhang C, Jia Q, Zhu L, Chen L, Li B, Guo X, Ye J, Tan Z, Wang L, Li S, Li XJ. SQSTM1 mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy (2021, IF=16.016)

12.   Yin P(第一作者), Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.EMBO Reports (2020, IF=8.807)

13.   Yin P(第一作者), Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathologica (2019, IF=18.174)