个人简介

杨甦，暨南大学粤港澳中枢神经再生研究院研究员，博士生导师，国家高层次引进青年人才，珠江人才计划拔尖青年。2008年本科毕业于南京大学生命科学学院生物技术专业；2014年于美国埃默里大学（Emory University）获得生物化学博士学位；2014年起在埃默里大学人类遗传学系从事博士后研究工作。2019年加入暨南大学。主要研究方向为神经退行性疾病（亨廷顿舞蹈症、脊髓小脑共济失调、阿尔兹海默症）的致病机制和干预手段，以及中脑星形胶质细胞源性神经营养因子的功能和作用机制。在Neuron，Journal of Clinical Investigation，Nature Communications，Science Advances，PNAS等国际著名学术期刊发表研究性论文30余篇。主持科技部重点研发计划课题，国家自然科学基金面上项目（2项）、青年项目。获得美国神经科学协会（Society for Neuroscience）颁发的职业发展奖。

代表性论文

1.     Eshu Ruan, Jingpan Lin, Zhao Chen, Qianai Sheng, Laiqiang Chen, Jiating He, Xuezhi Duan, Yiyang Qin, Tingting Xing, Sitong Yang, Mingtian Pan, Xiangyu Guo, Peng Yin, Xiao-Jiang Li, Hong Jiang, Shihua Li, Su Yang. Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice. Journal of Clinical Investigation, 2025 Jun 3;135(14):e178349

2.     Yiyang Qin, Laiqiang Chen, Wenzhen Zhu, Jiahong Song, Jingpan Lin, Yuwei Li, Jiawei Zhang, Xichen Song, Tingting Xing, Tingting Guo, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Qi Wang, Bang Li, Weili Yang, Peng Yin, Xiao-Xin Yan, Shihua Li, Xiao-Jiang Li, Su Yang. TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease. Science Advances, 2024 May 17;10(20):eadl2036.

3.     Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang. Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease. Molecular Neurodegeneration, 2024 Oct 18;19(1):75

4.     Hyunkyung Jeong, Yiyang Qin, Fangke Xu, Katarina Trajkovic, Myung Jong Kim, Nicolas Marotta, Kana Hamada, Ravi Allada, Su Yang, Dimitri Krainc. Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin. JCI Insight, 2026 Feb 23;11(4):e181013

5.     Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice. Cell Death & Disease, 2024 May 14;15(5):337.

6.     Su Yang, Huiming Yang, Luoxiu Huang, Luxiao Chen, Zhaohui Qin, Shihua Li, Xiao-Jiang Li. Lack of RAN-mediated toxicity in Huntington's disease knock-in mice. PNAS, 2020 Feb 25;117(8):4411-4417.

7.     Yiyang Qin, Shihua Li, Xiao-Jiang Li, Su Yang. CRISPR-based genome-editing tools for Huntington’s disease research and therapy. Neuroscience Bulletin, 2022 Nov;38(11):1397-1408

8.     Su Yang, Shanshan Huang, Marta A Gaertig, Xiao-Jiang Li, Shihua Li. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron, 2014 Jan 22;81(2):349-65.

9.     Su Yang, Renbao Chang, Huiming Yang, Ting Zhao, Yan Hong, Ha Eun Kong, Xiaobo Sun, Zhaohui Qin, Peng Jin, Shihua Li, Xiao-Jiang Li. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease. Journal of Clinical Investigation, 2017 Jun 30;127(7):2719-2724.

10.  Su Yang, Huiming Yang, Renbao Chang, Peng Yin, Yang Yang, Weili Yang, Shanshan Huang, Marta A Gaertig, Shihua Li, Xiao-Jiang Li. MANF regulates hypothalamic control of food intake and body weight. Nature Communications, 2017 Sep 18;8(1):579.

11.  Su Yang, Shihua Li, Xiao-Jiang Li. Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity. Cell Reports, 2018 Dec 4;25(10):2653-2659.e3.

12.  Jifeng Guo, Yiting Cui, Qiong Liu, Yang Yang, Yujing Li, Ling Weng, Beisha Tang, Peng Jin, Xiao-Jiang Li, Su Yang, Shihua Li. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Molecular Neurodegeneration, 2018 Jan 30;13(1):4.